(19) RU (11) 2055604 (13) C1

(51) 6A6IM 37/00, A61H39/00

(12) Description of the Invention to Russian Federation Patent

(21) 93045442/14

(22) 13.09.93

(46) 10.03.96 Bull. No. 7

(76) Petrenko Sergey Ivanovich

(56) 1. USSR Inventor's Certificate No. 942777, cl. A61N5/00, 1982

2. USSR Inventor's Certificate No. 1581326, cl. A61N1/00, 1990

(54) Device for Changing the Activity of a Biological Cell

(57) Applied in Medicine. An object – changing activity of one type of cells without changing the activity of other types of cells. Abstract of the Disclosure: a device for changing the activity of a biological cell is made as an integral element providing reception, storage and transmission of electromagnetic waves, and comprising a unit for temperature changing, connected with the integral element, located in close proximity to the biological cell.

Positive effect: the invention allows to use the device effectively for treating diseases caused by pathogenic and conditionally pathogenic microorganisms in the body of a man or animals. 10 claims, 3 figures.

This invention related to medicine, and, more particularly, to medical technique, and may be used for destroying pathogenic and conditionally pathogenic microorganisms in the body of a man or animals.

The apparatus for decimetre therapy is known, which comprises a self-exciting generator, connected with a power meter unit via a control unit, and a contact type emitter, seriesly connected with the power meter unit.[1] In the process of apparatus work a signal from the self-exciting generator, setting electromagnetic wave frequency, goes to the control unit, which provides amplifying, electromagnetic oscillation power adjusting and treating procedure duration setting. Then the signal goes to the power meter unit allowing to control a dosed power level, and futher to the emitter contacting directly with a patient.

Though the device provides improved precision of dosing the energy absorbed by a patient, it is not able to act selectively upon some types of biological cells.

A device for low-frequency therapy is known, comprising an electromagnetic oscillation receiver, a continuous electromagnetic wave generator, a pulse electromagnetic oscillation generator, a switching unit, a radiator, an electrode and a capacitor plate, the abovementioned electromagnetic oscillation generators being connected with the emitter, the electrode and the capacitor plate through the switching unit. Device action is based on the correction of the regulating system condition of human and animal organisms using a weak electromagnetic field of low frequency. The device operates in the two main modes: diagnostics and therapeutic action. In the diagnostic mode a pathologic bioresonance frequency (or frequency spectrum) of the biological object is determined by means of a receiver, a continuous electromagnetic wave generator and an electrode. After pathologic bioresonance frequency definition and taking into account other medical indications, a mode of action upon a pathologic biological object is set (distantly or locally). The type of signals (pulse or continuous), amplitude and waveform, therapeutic bioresonance frequency or frequency spectrum, as well as procedure duration are also defined. A type of electromagnetic oscillations, as well as therapeutic procedure duration are selected by the switching unit, connecting the pulse or continuous wave generator to irradiator, electrode or the capacitor plate.

The described device allows to correct the work of biologic cells with electromagnetic waves of low intensity. But this device is not also able to change the activity of biological cells of different kinds selectively and in doses.

It is an object of this invention to provide such a device for changing biological cell activity, which allows to change the activity of one type of cells without changing the activity of other types of cells by means of resonance interactivity between low intensity electromagnetic waves of the device and a cell at its bioresonance frequency.

The task is solved by using a device for changing biological cell activity, comprising a receiver and electromagnetic wave generator, located closely adjacent the cell, and which, according to the present invention, have a memory unit, connected with the receiver and generator, and a temperature changing unit, connected to the receiver, electromagnetic wave generator and memory unit, these receiver, electromagnetic wave generator and memory unit being made in a form of the integral unit. This allows to change the activity of one type of cells without changing the activity of others.

It is reasonable to use a solid material for the integral unit. It provides high reliability of the device operation. It is possible to use liquid substance as the integral unit. It allows to extend functional capabilities of the device. It is possible to use a crystal as solid substance for the integral unit. It helps to maintain device serviceability during a long period of time.

The temperature changing unit can be made in a form of a resistive element connected with an electric power source. It provides a broad range of temperature change of the integral unit. It is suitable to use a crystal semiconductor device as solid or liquid substance of the integral unit, and at least one semiconductor junction of the device with an electric power source connected to it as a temperature changing unit. This allows to minimize the device overall dimensions.

It is also possible to use a transistor as a semiconductor device, the emitter of which is connected directly to an electric power source, and the collector is connected via the switching unit, the base of the transistor being connected with its collector via a resistor. This enables to simplify the device. It is reasonable to provide a screening housing or cover for the device. It will protect the information stored in the memory unit from external action.

The walls of the screening housing or cover may be made of a water containing salt. Alongside with effective screening it will make possible to broaden the environment temperature range in which the device can operate.

The walls of the screening housing or cover may be hollow. This allows to use liquids or loose substances as screening material.

The wall cavities of the screening housing or cover may be filled with water. It will increase the screening efficiency.

Fig. 1 is a general block-diagram of the suggested device.

Fig. 2 is a schematic diagram of one of the embodiments of the invention.

Fig. 3 is one type of the screening housing and cover of the device of the invention.

The suggested device includes a receiver 1, a memory unit 2 and an electromagnetic wave generator 3, linked with each other, as well as a temperature changing unit 4 connected to each of the above units. The receiver 1, the memory unit 2 and the electromagnetic wave generator 3 may be connected with each other in different ways, however their series connection is here described to simplify understanding of the invention. The receiver 1, the memory unit 2 and the electromagnetic wave generator 3 are made as an integral unit 5.

Any solid substances, e.x. copper, graphite, polyethylene, rosin, wood, and so on, can be used as a solid substance for the integral unit 5. Any fluid, water, for example, can be used as liquid material. The most suitable materials for the integral unit 5 are those having crystal structure, high melting and boiling point, high chemical resistance, low electroconductivity and minimal amount of additives, for example diamond, garnet, germanium, and so on.

The temperature changing unit 4 of the integral unit 5 may be designed in the form of an electrical, mechanical, electromagnetic or any other energy source. In this case temperature changes of the integral unit 5 may be done, for example, by the heat generated when electric current goes through it, or by the heat generated during elastic deformation of the integral unit 5, or by absorbing electromagnetic waves, and so on. But the most efficient way is to use an element, connected to the source of electrical, chemical, mechanical, electromagnetic, etc. power and located in close proximity to the integral element 5 or contacting with it, as the temperature changing unit.

The device of the invention operates in the following way: at first, information about metabolic activity of sample cells is recorded to the memory unit 4 by any known way. For example, sample cells 6 of a particular kind are placed in close proximity to the integral element 5. The cells are known to have a certain metabolic activity, defined preliminarily by any known method. The integral unit 5 is then heated by the temperature changing unit, recording the information about the metabolic activity of the sample cells 6 at the bioresonance frequency F into the memory unit 2 with the help of the receiver 1. Heating of the integral unit 5 may be followed both by natural or forced cooling. Heating and cooling of the integral unit 5 can be done several times to improve information recording. Heating with the following cooling or cooling with the following heating compose a temperature changing cycle of the integral unit 5. Having recorded the information about metabolic activity of the sample cells 6 into the memory unit 2 the device is ready for the operation. Then a cell 7, the biological activity of which should be changed (further refferred to as an irradiated cell) is placed in close vicinity to the integral unit 5, and by means of the temperature changing unit 4 a temperature changing cycle of the integral unit 5 is carried out.

When changing the temperature of the integral unit 5, the generator 3 emits electromagnetic waves of low intensity at the bioresonance frequency F of the sample cells 6. As a result of the resonance interaction of the electromagnetic waves, radiated by the generator 4 of the integral unit 5 with the irradiated cell 7 at the bioresonance frequency F, the metabolic activity of the irradiated cell 7 became similar to the sample one.

The above recording and reproducting of the data about the metabolic activity of the sample cells 6 may be accomplished by means of the temperature changing unit 4 first in the mode of cooling the integral unit 5, followed by its heating.

A semiconductor crystal 8 (Fig. 2) may be used as an integral unit 5. In this case at least one semiconductor junction of this device with a source of electric power 9 connected to it is used as a temperature changing unit 4.

Fig. 2 shows a version of the embodiment of this invention wherein a transistor is used as a semiconductor device 8, the emitters Ý of which is connected directly to the electric power source 9, whereas the collector Ê is connected via a switch 10, the transistor Base Á being connected with its collector K via a resistor 11.

The arrangement shown in Fig. 2 operates in the following way.

At first, data about metabolic activity of sample cells 6 are recorded to the transistor crystal by any known way. For example, the sample cells 6, having predermined metabolic activity, defined by any known method, are placed in close proximity to the transistor. The electric power source 9, connected with the transistor is switched on by closing the switch 10. Heat generating in the semiconductor junctions warms the transistor crystal. The resistor 11 sets the transistor operating mode and, accordingly, its crystal heating temperature. In heating the crystal data about the metabolic activity of the sample cells 6 are recorded onto it. Then, by means of the switch 10 the power source 9 is disconnected. The transistor crystal is cooled. Data may also be recorded in the mode of transistor crystal cooling. After completion of recording the information about the metabolic activity the sample cells 6 the device is ready for operation.

Then, the irradiated cell 7 (or a group of cells) is placed in close proximity to the transistor and a cycle of heating with the following crystal cooling is carried on by closing and then disclosing the switch 10. As a result of resonance interaction of the low intensity electromagnetic waves of the device and the irradiated cell 7 at the bioresonance frequency F, the metabolic activity of the irradiated cell is set similar to the activity of the sample one.

To maintain proper metabolic activity of irradiated cells 7 during a long period of time radiation sessions are repeated in certain intervals of time. Metabolic data are not recorded once again for repeated sessions.

Now let’s consider the device operation on a concrete example of changing the metabolic activity of bacterial Staphylococcus aureus cells in the human body. At first, Staphylococcus aureus cell culture is isolated and set into a low metabolic activity condition by any known technique. Then using any known method information about the low metabolic activity of Staphylococcus aureus cells is recorded into the memory 2 of the integral unit 5. For instance, the culture of these cells is placed in close proximity to the integral unit 5 and a cycle of heating with the following cooling of the integral unit 5 by means of the temperature changing unit 4 is carried on.

Then the device is placed in close proximity to the man and using the temperature changing unit 4 a cycle of heating and cooling the integral unit 5 is accomplished. A resonance interaction of low intensity electromagnetic waves of the device and Staphylococcus aureus cells, located in the human body occurs at the bioresonance frequency F. As a result Staphylococcus aureus cells in the human or animal body are set to the state of the low metabolic activity similar to this of the Staphylococcus aureus sample cells.

To maintain the low metabolic activity of the Staphylococcus aureus cells in the human or animal body during a long period of time and to destroy them subsequently by the human immune system, it is necessary to carry on several cycles, for example, every 6 hours during 3-5 days.

Application of high-quality crystals provides long and stable reproduction of the information recorded. Decrease of information level about the metabolic cell activity, recorded on a transistor crystal does not exceed 3% of the initial value after 1000 cycles of heating and cooling transistor crystals.

The device allows to record and store on a single crystal the information about metabolic activity of sample cells 6, posessing different bioresonance frequencies F1, F2, F3... Fn and to affect simultaneously similar types of cells at bioresonance frequencies F1, F2, F3... Fn, accordingly. To provide safe storage of the information recorded, the device is placed into a screening housing 12 with a cover 13, which protects the device from sources of intensive thermal radiation, e.x. burning alcohol, petrol, matches, cigarettes and so on.

Fig. 3 shows a certain embodiment of the screening housing 12 and the cover 13. The integral unit 5 and the temperature changing unit 4 are positioned into the housing 12. The housing 12 and the cover 13 can be made of water containing salt, such as MgSO₄·7H₂O, KNaC₄H₄O₆·4H₂O.

The walls of the housing 12 and the cover 13 can be hollow and the wall cavities of the housing 12 and the cover 13 can be filled with water.

The suggested device is suitable for treating diseases caused by pathogenic and conditionally pathogenic microorganisms in the human or animal body.

Decrease in the rate of microorganism development occurs by setting a potential on their cell membranes at a level, corresponding to their low metabolic activity. The rate of destroying microorganisms by the human or animal immune system increases automatically as the amount of toxins excreted by bacteria due to the decrease of their metabolic activity diminishes. The device can be used successfully to treat such diseases as pneumonia, quinsy, rheumatic arthritis, influenza, meningitis, etc. A high selectivity and a dosed way of action, simplicity and reliability of the device operation in combination with its small dimensions enables the application of the device of this invention for treating various diseases of a man and animals both in clinics and out-patient environments. The device has no contraindications to parallel treating with other methods.

We claim:

1. The device for changing biological cell activity, comprising a unit of action receiving and transmitting electromagnetic waves, located closely adjacent a biologic cell, wherein said unit of action is made in the form of an integral unit able to store the received electromagnetic waves, comprising also a temperature changing unit, connected with said unit of action.
2. The device of claim 1, wherein said unit of action is made in the form of solid substance.
3. The device of claim 1, wherein said unit of action is made in the form of liquid substance.
4. The device of claim 2, wherein a crystal is used as solid substance.
5. The device of claim 1, wherein said temperature changing unit is made in a form of resistive element, connected to the source of electric power.
6. The device of claim 1, wherein semiconductor device crystal is used as solid substance for said unit of action, and at least one semiconductor junction of the semiconductor device with said electric power source connected to it is used as a temperature changing unit.
7. The device of claim 6, wherein a transistor is used as a semiconductor device, the emitter of which is directly connected to said electric power source, and the collector is connected via switch, whereas the transistor base being connected with its collector via a current driving element.
8. The device of claims 1-7. Wherein it is provided with a screening housing and a cover.
9. The device of claim 8, wherein said screening housing and the cover are made of such material as water containing salt.
10. The device of claim 8, wherein the walls of said screening housing and the cover are hollow.
11. The device of claim 8, wherein the wall cavities of said screening housing and the cover are filled with water.

Fig. 1

Fig. 2

Fig. 3